朱建華,女,博士,暨南大學(xué)藥學(xué)院副教授,碩士研究生導(dǎo)師,廣東省高等學(xué)?!扒О偈こ獭钡谄吲<?jí)培養(yǎng)對(duì)象,廣州市珠江科技新星。主要研究方向:天然藥物活性成分的生物合成和生物轉(zhuǎn)化。

個(gè)人簡(jiǎn)介

朱建華,作為主持人承擔(dān)了1項(xiàng)國(guó)家自然科學(xué)基金課題、1項(xiàng)廣州市珠江科技新星項(xiàng)目、1項(xiàng)省自然科學(xué)基金課題、1項(xiàng)中醫(yī)藥局科研項(xiàng)目以及2項(xiàng)暨南大學(xué)創(chuàng)新與培育基金課題的研究;作為第二申請(qǐng)人承擔(dān)了1項(xiàng)廣州市科技重大專項(xiàng)、作為第三申請(qǐng)人承擔(dān)了2項(xiàng)國(guó)家自然科學(xué)基金課題、作為子課題負(fù)責(zé)人承擔(dān)了2項(xiàng)國(guó)家科技重大專項(xiàng)課題的研究工作。目前,已在?Process Biochemistry?、?Fitoterapia?、?ChineseChemicalLetters?、?中國(guó)藥學(xué)雜志?、?中草藥?、?中藥材?等國(guó)內(nèi)外期刊上發(fā)表文章25篇,包括SCI論文10篇;參編專著2部,參編實(shí)驗(yàn)指導(dǎo)書3部;申請(qǐng)發(fā)明專利4項(xiàng),包括國(guó)際專利1項(xiàng)。參加學(xué)術(shù)團(tuán)體任職情況:國(guó)家自然科學(xué)基金同行評(píng)議專家,廣東核磁共振學(xué)會(huì)成員,?NaturalProductResearch?審稿專家。

科研成果

主要研究方向:

天然藥物活性成分的生物合成和生物轉(zhuǎn)化

近三年主持及承擔(dān)的項(xiàng)目:
項(xiàng)目名稱起止時(shí)間下達(dá)任務(wù)單位經(jīng)費(fèi)(萬(wàn)元)課題組排名
新型誘導(dǎo)子青蒿酸對(duì)長(zhǎng)春花培養(yǎng)物中生物堿合成的誘導(dǎo)與代謝調(diào)控機(jī)制研究2012-01-01--2014-12-31國(guó)家自然科學(xué)基金221
基于銀杏干細(xì)胞培養(yǎng)體系的海松二烯生物合成銀杏內(nèi)酯及其代謝調(diào)控研究2014-01-01--2016-12-31廣州市珠江科技新星301
新型誘導(dǎo)子青蒿酸對(duì)長(zhǎng)春花生物堿誘導(dǎo)及調(diào)控機(jī)制研究2011-10-10--2012-10-31廣東省自然科學(xué)基金基金31
基于植物干細(xì)胞培養(yǎng)體系的喜樹堿生物合成及其代謝調(diào)控研究2012-01-01--2013-12-31暨南大學(xué)培育與創(chuàng)新基金101
新型誘導(dǎo)子青蒿酸對(duì)長(zhǎng)春花細(xì)胞中生物堿合成的誘導(dǎo)與代謝調(diào)控機(jī)制研究2011-01-01--2011-12-31暨南大學(xué)培育與創(chuàng)新基金2.51
展開表格近年發(fā)表論文情況:

1.Novel biotransformation processes of dihydroartemisinic acid and artemisinic acid to their hydroxylated deri-vatives by two plant cell culture systems. Process Biochemistry, 2010, 45: 1652-1656.(SCI,第一作者)

2. Enhancementofvindolineandvinblastineproductioninsuspension-culturedcellsofCatharanthusroseus by artemisinicacidelicitation.WorldJMicrobiolBiotechnol.publishedonline,2013,6:DOI10.1007/s11274-013-1432-z.(通訊作者)

3.Two new compounds from transgenicPanax quinquefolium. Fitoterapia, 2010, 81: 339-342.(SCI, 第一作者)

4.A new ceramide from transgenic crown galls ofPanax quinquefolium. Chinese Chemical Letters, 2009, 20: 447-449.(SCI,第一作者)

5.Three sesquiterpene compounds biosynthesized from artemisinic acid using suspension-cultured cells ofAverrhoa carambola. Natural Product Research, 2012, 26(15): 1388-1394.(SCI,第二作者)

6. Biotransformation of paeonol and emodin by transgenic crown galls ofPanax quinquefolium.Applied Bioche-mistry and Biotechnology, 2010, 160: 1301-1308. (SCI,第三作者)

7.Biotransformation of eugenol by transgenic crown galls ofPanax quinquefolium and cell suspension cultures ofNicotiana tabacum. World Journal of Microbiology and Biotechnology, 2010, 26: 1201-1205.(SCI,第三作者)

8.Stereo and region-selective biosynthesis of two new dihydroartemisinic acid glycosides by suspension-cultured cells ofArtemisia annua. Pharmacognosy Magazine, accepted on 21/Feb/2013. (SCI,第一作者)

9.Biosynthesis pathways of ginkgolides. Pharmacognosy Reviews, accepted on 09/Jan/2013. (SCI,第二作者)

10. ANewAntiproliferativeandAntioxidantPeptideIsolatedfromArcasubcrenata.Marinedrugs,2013, 11:1800-1814.(SCI,第四作者)

11.Impact of artemisinic acid on the growth and catharanthine accumulation in Catharanthus roseus cell cultures. Journal of Medicinal Plants Research, 2012, 6(10): 2019-2028. (共同第一作者)

12.Jianhua Zhu, Wei Wen, Yanshan Hu, Yu Tang, Rongmin Yu: Hydroxyl Octadecenoic Acids Biosynthesized by Crown Galls of Panax quinquefolium Induced by Artermisinic Acid (in English). Journal of Chinese Medicinal Materials. 35(6): 869-872. (第一作者)